The podcast delves into the science of aging, emphasizing that aging is driven by external forces like gravity, radiation, and oxidative stress, which are unavoidable. However, the potential lies in the body's ability to resist these forces through repair mechanisms. The discussion highlights the shift in perception over the past 30 years, where aging research has moved from being a neglected field to a burgeoning area of study. The identification of mutations that can increase lifespan in animal models has opened up possibilities for interventions that could extend human lifespan and healthspan. The conversation also touches on the importance of lifestyle factors, which account for 93% of longevity, and the role of genetic factors, particularly in those with centenarian relatives. The podcast explores various interventions, including lifestyle changes, nutraceuticals, and pharmaceuticals, that can activate longevity pathways. It also discusses the emerging field of biological age measurement through various clocks, emphasizing the importance of consistent measurement to track the effectiveness of interventions. The conversation concludes with insights into the potential of systems biology and AI to revolutionize our understanding and treatment of aging.