The video explores the widespread use of proton pump inhibitors (PPIs) for treating acid reflux and their potential long-term side effects, such as nutritional deficiencies, including vitamin B12, magnesium, and calcium. These deficiencies can lead to serious health issues like depression, neurological problems, and osteoporosis. The speaker emphasizes that PPIs are often overprescribed due to lifestyle and dietary habits, with many users not benefiting from them. The video suggests a functional medicine approach to address heartburn by identifying root causes, such as a weak lower esophageal sphincter, obesity, certain foods, and stress. It recommends dietary changes, stress management, and natural supplements like licorice root and melatonin to alleviate symptoms and promote gut health. The speaker also highlights the importance of addressing lifestyle factors and incorporating nutrient-dense foods to manage reflux effectively without relying on medications.