The liver, weighing about three and a half pounds and located under the right rib cage, is the largest internal organ and performs over 300 functions. Despite its complexity, modern medicine in 2024 still cannot fully replicate its functions. The liver is essential for metabolism, including proteins, lipids, fats, and carbohydrates, and plays a significant role in immune function. It synthesizes proteins crucial for blood clotting, and its dysfunction can lead to bleeding disorders. The liver is also responsible for detoxifying pharmacologic agents, supplements, and environmental toxins. Additionally, it manages bile acid production and nutrient load handling. A key aspect of its function is regulating blood glucose levels, maintaining them within a narrow range crucial for survival. The liver's role in managing lipoproteins, including their clearance and generation, is another critical function that often goes underappreciated.