The initial research into sodium bicarbonate focused on its potential to buffer acid and enhance short-term endurance, particularly in activities like 400 to 800-meter runs. The theoretical basis suggested that it could significantly improve performance. However, early trials with high doses led to severe side effects, such as explosive diarrhea, due to the reaction of strong bases with stomach acids. This highlighted the importance of careful dosing. Recent strategies have shifted towards smaller, more controlled doses over extended periods to mitigate these side effects while still aiming to enhance performance. This approach contrasts with the common practice in pre-workout supplements where users often take multiple scoops, which is not advisable with sodium bicarbonate due to its potent effects.